The coagulation cascade in hemophilia A.
The blood clotting process is controlled by a series of events that scientists call the coagulation cascade. The coagulation cascade is complicated because it involves a cast of important characters and many different pathways and connections. 5 It has taken scientists years to unlock its mysteries, and our understanding of the cascade is ever-evolving, even today.
In hemophilia A, one of the important characters, known as factor VIII, is either missing or at a low level. This interrupts the coagulation cascade and prevents blood from clotting. 6
Scientists are studying different approaches to continuing the coagulation cascade. The hope is that more research may offer more treatment options for people living with hemophilia A.
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